منابع مشابه
Plasminogen Receptors
1Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-3020, La Jolla, CA 92037, USA 2Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA 3Department of Biochemistry and Molecular Biology, Sir Charles Tupper Medical Building, Dalhousie University, 5850 College Street, Halifax, NS,...
متن کاملBacterial plasminogen activators and receptors.
Invasive bacterial pathogens intervene at various stages and by various mechanisms with the mammalian plasminogen/plasmin system. A vast number of pathogens express plasmin(ogen) receptors that immobilize plasmin(ogen) on the bacterial surface, an event that enhances activation of plasminogen by mammalian plasminogen activators. Bacteria also influence secretion of plasminogen activators and th...
متن کاملRegulation of plasminogen receptors.
Many eukaryotic and prokaryotic cells bind plasminogen in a specific and saturable manner. When plasminogen is bound to cell-surface proteins with C-terminal lysines via its lysine binding sites, its activation to plasmin is accelerated, and cell-bound plasmin is protected from inactivation by natural inhibitors. Plasmin mediates direct or indirect degradation of the extracellular matrix, and b...
متن کاملTissue-type-plasminogen-activator-associated fibrinolysis in orthotopic liver transplantation.
ORTHOTOPIC liver transplantation is frequently associated with hemostatic disorders and a bleeding diathesis.I.2 Accelerated fibrinolysis has been recognized as an important component of the hemostatic defectY The origin of this fibrinolytic activity, however, is still unclear. We investigated the role of tissue-type plasminogen activator (tPA). a potent activator of the fibrinolytic system, in...
متن کاملFibrinolysis in pregnancy: a study of plasminogen activator inhibitors.
During pregnancy the plasma concentration of two different inhibitors of plasminogen activators (PAIs) increases. The only one found in the plasma of nonpregnant women (PAI1) is immunologically related to a PAI of endothelial cells; its plasma activity, as deduced from the inhibition of single-chain tissue-type plasminogen activator (t-PA), increased from 3.4 +/- 2.3 U/mL (mean +/- 95% confiden...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22041712